Centessa

#药闻简讯# 2026年3月31日，$Centessa(CNTA)$ 是一家临床阶段公司，致力于开发用于治疗白天过度嗜睡和其他神经系统疾病的新型药物。该公司今天宣布$礼来(LLY)$ 已达成最终协议收购 Centessa。
Centessa公司正在推进一系列食欲素受体2 (OX2R) 激动剂的研发，旨在通过作用于睡眠-觉醒周期中至关...

Centessa Pharmaceuticals的ORX750（现名cleminorexton），采用环化，环丙基取代，五元环替换成六元环来突破武田的TAK-861专利，最终分子的效力和选择性得到提高。效力提升20倍：EC50从TAK-861的约2.5 nM降至0.11 nM选择性提升3倍：OX2R vs OX1R从约3000倍提升至9800倍。
$Centessa(CNTA)$

$Centessa(CNTA)$
摘要
Centessa Pharmaceuticals是一家专注于开发食欲素受体2（OX2R）激动剂的临床阶段生物制药公司。2026年3月31日，公司被礼来以最高78亿美元的价格收购，这一交易标志着OX2R激动剂赛道正式进入主流视野。
Centessa的核心价值不在于“第一个”上市，而在于“最好的...

$Centessa(CNTA)$ 144 Report of proposed sale of securities Accession Number: 0001969223-26-000346  Act: 33  Size: 8 KB 网页链接

$Centessa(CNTA)$ 8-K Current report, item 5.02 Accession Number: 0001193125-26-051424  Act: 34  Size: 189 KB 网页链接

$Centessa(CNTA)$ 144 Report of proposed sale of securities Accession Number: 0001969223-26-000076  Act: 33  Size: 6 KB 网页链接

$Centessa(CNTA)$ 4 Statement of changes in beneficial ownership of securities Accession Number: 0001470831-26-000096  Size: 9 KB 网页链接

$Centessa(CNTA)$ 4 Statement of changes in beneficial ownership of securities Accession Number: 0001470831-26-000090  Size: 11 KB 网页链接

$Centessa(CNTA)$ 4 Statement of changes in beneficial ownership of securities Accession Number: 0001470831-26-000092  Size: 15 KB 网页链接

$Centessa(CNTA)$ 144 Report of proposed sale of securities Accession Number: 0001969223-26-000054  Act: 33  Size: 11 KB 网页链接

$Centessa(CNTA)$ SCHEDULE 13G/A [Amend] Statement of Beneficial Ownership by Certain Investors Accession Number: 0000315066-26-000600  Act: 34  Size: 11 KB 网页链接

$Centessa(CNTA)$ DFAN14A Additional definitive proxy soliciting materials filed by non-management and Rule 14(a)(12) material Accession Number: 0001193125-26-133360  Act: 34  Size: 57 KB 网页链接

$Centessa(CNTA)$ DEFA14A Additional definitive proxy soliciting materials and Rule 14(a)(12) material Accession Number: 0001193125-26-134727  Act: 34  Size: 28 KB 网页链接

$Centessa(CNTA)$ S-8 Securities to be offered to employees in employee benefit plans Accession Number: 0001847903-26-000026  Act: 33  Size: 329 KB 网页链接

$Centessa(CNTA)$ 4 Statement of changes in beneficial ownership of securities Accession Number: 0001470831-26-000084  Size: 9 KB 网页链接

$Centessa(CNTA)$ 144 Report of proposed sale of securities Accession Number: 0001969223-26-000355  Act: 33  Size: 5 KB 网页链接

$Centessa(CNTA)$ 4/A [Amend] Statement of changes in beneficial ownership of securities Accession Number: 0001470831-26-000279  Size: 15 KB 网页链接

$Centessa(CNTA)$ DEFA14A Additional definitive proxy soliciting materials and Rule 14(a)(12) material Accession Number: 0001193125-26-134666  Act: 34  Size: 934 KB 网页链接

$Centessa(CNTA)$ 144 Report of proposed sale of securities Accession Number: 0001969223-26-000400  Act: 33  Size: 5 KB 网页链接

$Centessa(CNTA)$ 4 Statement of changes in beneficial ownership of securities Accession Number: 0001470831-26-000267  Size: 7 KB 网页链接